Non-Clinical Vascular Infusion Technology, Two Volume Set: Science and Techniques (Hardcover)

VOLUME I:

Body Fluid Dynamics
Introduction
Composition and units of measurement
Compartmentalization and Distribution
Movement between Compartments/Exchange
Body Fluid Homeostasis
Summary
References

Physico-Chemical Factors
Introduction
Osmolality
Acid-Base Balance
Viscosity
Surface Tension
Diffusion
Summary of Infusion Forces
References

Vascular Infusion Dynamics
Essential physiology
Intravenous Delivery Rates and Volumes
References

Formulation Considerations, Co-author: Kevin Sooben
Introduction
Formulation selection strategy
Study design and species/strain
The properties of the compound
Strategies for dealing with poor solubility
Unwanted formulation effects
Excipient toxicity
Strategies for dealing with injection site reactions and haemolysis
Strategies for dealing with poor stability
Sterility
Conclusion
References

Prestudy analytical assessments:

Equipment compatibility, Co-author: James Baker
Introduction
Stability of the formulation with the formulation storage vessel
Compatibility
Choice of material
References
Haemocompatibility, Co-author: Sophie Hill
Introduction
Objectives.
Methods of assessing haemocompatibility
Discussion
Conclusion
References

Annex: Common excipients and vehicles

VOLUME II:

Rat
Jennifer Sheehan, Duncan Patten and Vasanthi Mowat

Mouse
Hans van Wijk and Alice J M Fraser

Dog
John Cody Resendez and David Rehagen

Primate
Christine Copeman and Stephanie Clubb

Reproductive models

Minipig
Peter Glerup, Mikala Skydsgaard and Gitte Jeppesen

Juvenile animals
Teresa R. Gleason and George A. Parker

Marmoset
Dr. Sven Korte, Dr. Piotr Nowak, Dr. Jorg Luft and Dr. Birgit Niggemann