Non-Clinical Vascular Infusion Technology, Volume I: The Science (Hardcover)

Body Fluid Dynamics
Introduction
Composition and units of measurement
Compartmentalization and Distribution
Movement between Compartments/Exchange
Body Fluid Homeostasis
Summary
References

Physico-Chemical Factors
Introduction
Osmolality
Acid-Base Balance
Viscosity
Surface Tension
Diffusion
Summary of Infusion Forces
References

Vascular Infusion Dynamics
Essential physiology
Intravenous Delivery Rates and Volumes
References

Formulation Considerations, Co-author: Kevin Sooben
Introduction
Formulation selection strategy
Study design and species/strain
The properties of the compound
Strategies for dealing with poor solubility
Unwanted formulation effects
Excipient toxicity
Strategies for dealing with injection site reactions and haemolysis
Strategies for dealing with poor stability
Sterility
Conclusion
References

Prestudy analytical assessments:

Equipment compatibility, Co-author: James Baker
Introduction
Stability of the formulation with the formulation storage vessel
Compatibility
Choice of material
References
Haemocompatibility, Co-author: Sophie Hill
Introduction
Objectives.
Methods of assessing haemocompatibility
Discussion
Conclusion
References

Annex: Common excipients and vehicles