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· 분류 : 외국도서 > 의학 > 신경학
· ISBN : 9781489940407
· 쪽수 : 319쪽
목차
The Paradox of Prion Disease. Human Spongiform Encephalopathy: Clinical Presentation and Diagnostic Tests. Neuropathological Diagnosis of Human Prion Disease: Morphological Studies. Neuropathological Diagnosis of Human Prion Disease: PrP Immunocytochemical Techniques. The Diagnosis of Bovine Spongiform Encephalopathy (BSE) and Scrapie by Detection of BSE Fibrils or Scrapie-Associated Fibrils (SAF) by Transmission Electron Microscopy and of the Abnormal Protein Isoform (PrPSc) by Immunoblotting. Exposure to, and Inactivation of, the Unconventional Agents that Cause Transmissible Degenerative Encephalopathies. Surveillance of Prion Diseases in Humans. Environmental Causes of Human Spongiform Encephalopathy. Bovine Spongiform Encephalopathy: Methods of Analyzing the Epidemic in the United Kingdom. Handling the BSE Epidemic in Great Britain. Special Problems of Genetic Counseling in Adult Onset Diseases: Huntington's Disease as a Model. Genotyping and Susceptibility of Sheep to Scrapie. Strain Typing Studies of Scrapie and BSE. PrP-Deficient Mice in the Study of Transmissible Spongiform Encephalopathies. Transgenic Approaches to Prion 'Species-Barrier' Effects. Methods for Studying Prion Protein (PrP) Metabolism and the Formation of Protease-Resistant PrP in Cell Culture and Cell-Free Systems. Immunohistochemistry of Resinated Tissues for Light and Electron Microscopy. Index.