Innovations for Next-Generation Antibody-Drug Conjugates (Paperback)

· 제목 : Innovations for Next-Generation Antibody-Drug Conjugates (Paperback) 
· 분류 : 외국도서 > 의학 > 종양학
· ISBN : 9783030086275
· 쪽수 : 357쪽
· 출판일 : 2019-02-08

Chapter 1. “Introduction: Motivations for Next-Generation ADCs” -Marc Damelin

Chapter 2. “Combining ADCs with Immuno-oncology Agents” -- Philipp Muller, Jonathan Rios-Doria, Jay Harper and Anthony Cao

Chapter 3.  “Improving the Safety Profile of ADCs” -- MagaliGuffroy, HadiFalahatpisheh and Martin Finkelstein

Chapter 4. “Utility of PK-PD Modeling and Simulation to Improve Decision Making for Antibody-Drug Conjugate Development” -- Aman P. Singh and Dhaval K. Shah

Chapter 5.“Regulatory Considerations and Companion Diagnostics” ? Elizabeth VanAlphen and Omar Perez

Chapter 6. “ADC Process Development and Manufacturing” ? Olivier Marcq

Chapter 7. “HER2-Targeted ADCs: At the forefront of ADC technology development” ? Kevin J. Hamblett

Chapter 8. “Next generation payloads for ADCs” ? L. Nathan Tumey

Chapter 9.“Delivering more payload: High DAR ADCs” - Natalya Bodyak and Alexander V.Yurkovetskiy

Chapter 10.“Site-Specific Antibody Drug Conjugates” ? Feng Tian, Dowdy Jackson and Yun Bai

Chapter 11. “Bispecific and Biparatopic Antibody-Drug Conjugates” -- Frank Comer, Changshou Gao and Steve Coats

Chapter 12. “Targeting drug conjugates to the tumor microenvironment: Probody Drug Conjugates” -- Jack Lin and Jason Sagert

Chapter 13.“Antibody-Drug Conjugates: Targeting the Tumor Microenvironment” ? Alberto Dal Corso, SamueleCazzamalli and Dario Neri

Chapter 14. “Next Horizons: ADCs Beyond Oncology” -- Shan Yu, Andrew Lim and Matthew S. Tremblay