Innovations for Next-Generation Antibody-Drug Conjugates (Hardcover, 2018)

Chapter 1. "Introduction: Motivations for Next-Generation ADCs" -Marc Damelin Chapter 2. "Combining ADCs with Immuno-oncology Agents" -- Philipp Muller, Jonathan Rios-Doria, Jay Harper and Anthony Cao Chapter 3. "Improving the Safety Profile of ADCs" -- MagaliGuffroy, HadiFalahatpisheh and Martin Finkelstein Chapter 4. "Utility of PK-PD Modeling and Simulation to Improve Decision Making for Antibody-Drug Conjugate Development" -- Aman P. Singh and Dhaval K. Shah Chapter 5."Regulatory Considerations and Companion Diagnostics" - Elizabeth VanAlphen and Omar Perez Chapter 6. "ADC Process Development and Manufacturing" - Olivier Marcq Chapter 7. "HER2-Targeted ADCs: At the forefront of ADC technology development" - Kevin J. Hamblett Chapter 8. "Next generation payloads for ADCs" - L. Nathan Tumey Chapter 9."Delivering more payload: High DAR ADCs" - Natalya Bodyak and Alexander V.Yurkovetskiy Chapter 10."Site-Specific Antibody Drug Conjugates" - Feng Tian, Dowdy Jackson and Yun Bai Chapter 11. "Bispecific and Biparatopic Antibody-Drug Conjugates" -- Frank Comer, Changshou Gao and Steve Coats Chapter 12. "Targeting drug conjugates to the tumor microenvironment: Probody Drug Conjugates" -- Jack Lin and Jason Sagert Chapter 13."Antibody-Drug Conjugates: Targeting the Tumor Microenvironment" - Alberto Dal Corso, SamueleCazzamalli and Dario Neri Chapter 14. "Next Horizons: ADCs Beyond Oncology" -- Shan Yu, Andrew Lim and Matthew S. Tremblay