Phosphodiesterases: CNS Functions and Diseases (Paperback, Softcover Repri)

Part I. PDEs and Signaling, Circuitry, and Implications of CNS Functions and Disorders.- 1. Phosphodiesterase Diversity and Signal Processing within cAMP Signaling Networks.- 2. Current Understanding of PDE10A in the Modulation of Basal Ganglia Circuitry.- 3. Interaction of Cdk5 and cAMP/PKA Signaling in the Mediation of Neuropsychiatric and Neurodegenerative Diseases.- 4. The PDE4 cAMP-specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-enhancing Action.- 5. Phosphodiesterase-4B as a Therapeutic Target for Cognitive Impairment and Obesity-related Metabolic Diseases.- Part II. PDEs in Cognition of Aging and Alzheimer's Disease.- 6. From age-related Cognitive Decline to Alzheimer's Disease: A Translational Overview of the Potential role for Phosphodiesterases.- 7. The Past, Present, and Future of Phosphodiesterase-4 Modulation for age-induced Memory Loss.- 8. A Role for Phosphodiesterase 11A (PDE11A) in the Formation of Social Memories and the Stabilization of Mood.- 9. Role of PDE9 in Cognition.- Part III. PDEs in Parkinson's and Huntington's Diseases.- 10. Regulation of Striatal Neuron Activity by Cyclic Nucleotide Signaling and Phosphodiesterase Inhibition: Implications for the Treatment of Parkinson's Disease.- 11. Role of Phosphodiesterases in Huntington's Disease.- Part IV. PDEs and Psychiatric Disorders.- 12. The role of Phosphodiesterase-2 in Psychiatric and Neurodegenerative Disorders.- 13. Phosphodiesterase 1: A Unique Drug Target for Degenerative Diseases and Cognitive Dysfunction.- 14. PDE Inhibitors for the Treatment of Schizophrenia.- Part V. PDEs and Others.- 15. Targeting Phosphodiesterases in Pharmacotherapy for Substance Dependence.- 16. Genetic Understanding of Stroke Treatment: Potential role for Phosphodiesterase Inhibitors.- 17. A unique sub-pocket for Improvement of Selectivity of Phosphodiesterase Inhibitors in CNS.