Protein Degradation: Ubiquitin and the Chemistry of Life (Hardcover)

Brief history of protein degradation and the ubiquitin system (Avram Hershko) N-terminal ubiquitination: Not such a rare modification anymore (Aaron Ciechanover) Evolutionary origin of the activation step during ubiquitin dependent protein degration (Hermann Schindelin) RING fingers and relatives: determination of protein fate (Allan M. Weissman, Kevin L. Lorick, Yien-Che Tsai, Yili Yang) Ubiquitin conjugation enzymes (Cecile M. Pickart, Michael J. Eddins) The SCF ubiquitin E3 ligase (Hui Zhang, Leigh A. Higa) Structural biology of ubiquitin-protein ligases (Ning Zheng, Nikola P. Pavletich) The deubiquitinating enzymes (Nathaniel S. Russel, Keith Wilkinson) The 26S proteasome (Martin Rechsteiner) Molecular machines for protein degradation (Robert Huber, Matthias Bochtler, Michael Groll, Hans Brandstetter, Tim Clausen) Proteasome regulator, PA700 (19S regulatory particle)(George DeMartino, Cezary Wojcik) Bioinformatics of ubiquitin domains and their binding partners (Kay Hofmann) The COP9 signalosome: Its possible role in the ubiquitin system (Wolfgang Dubiel, Dawadschargal Bech-Otschir, Barbara Kapelari).