Fragment-Based Approaches in Drug Discovery (Hardcover)

PART 1: CONCEPT AND THEORY
The concept of fragment-based ligand design
Multivalency in Ligand Design
Entropic consequences of linking ligands
Location of Binding Sites on Proteins by the Multiple Solvent Crystal Structure Method
PART 2: FRAGMENT LIBRARY DESIGN AND COMPUTATIONAL APPROACHES
Cheminformatics approaches to fragment-based lead discovery
Structural fragments from marketed oral drugs
Fragment docking to proteins with the multi-copy simultaneous search (MCSS) methodology
PART 3: EXPERIMENTAL TECHNIQUES
NMR - guided fragment assembly
SAR by NMR: an analysis of ptency gains realized through fragment-linking and fragment-elaboration strategies for lead generation
Pyramid: an integrated platform for fragment-based drug discovery
Fragment-based lead discovery and optimization using X-ray crystallography
Synergistic use of protein crystallography and solution-phase NMR spectroscopy in structure-based drug design: strategies and tactics
Ligand SAR using electrospray ionization mass spectrometry
Tethering
PART 4: EMERGING TECHNOLOGIES
Click chemistry for drug discovery
Dynamic combinatorial diversity in drug discovery