Target Discovery and Validation: Methods and Strategies for Drug Discovery (Hardcover)

Introduction to target discovery and target validation

PART 1: BIOCHEMICAL-BASED APPROACHES
Targeted/annotated libraries and target profiling for target discovery
Affinity-based methods using chemoproteomics for target identification
Activity based protein profiling
Kinobeads type approach
Label-free techniques for target discovery and validation
Chemical strategies for target validation

PART 2: BIOLOGY-BASED APPROACHES
Cell biology techniques for target validation
Understanding the broader phenotype
Gene manipulation/modulation
Yeast three hybrid system

PART 3: INFORMATICS-BASED APPROACHES
Computational Approaches for target inference
Bioinformatics approaches
Investigating the broader phenotype of a compound

PART 4: CASE STUDIES
Case study 1
Case study 2
Case study 3

Conclusions