Handbook of Internal Medicine

01 Gastroenterology
Ⅰ. Upper GI disease
1. Esophageal motility disorder…………………………………………………………1
2. GERD (Gastroesophageal reflux disease)… ………………………………………4
3. Various esophagitis… …………………………………………………………………7
4. Gastropathy and gastritis … ……………………………………………………… 10
5. Helicobacter pylori…………………………………………………………………… 12
6. Peptic ulcer disease (PUD)………………………………………………………… 14
7. NSAID induced gastrointestinal damage … …………………………………… 17
8. Gastric polyps … …………………………………………………………………… 19
9. 위선종과 조기위암의 내시경 치료… ……………………………………………… 20
10. Gastrointestinal bleeding ………………………………………………………… 24
Ⅱ. Lower GI disease
1. Constipation의 진단과 치료 … …………………………………………………… 32
2. Diarrhea ……………………………………………………………………………… 42
3. Ischemic diseases of the bowel…………………………………………………… 48
4. Infectious gastroenteritis… ………………………………………………………… 56
5. Inflammatory bowel diseases……………………………………………………… 60
6. Intestinal tuberculosis (대한소화기학회 가이드 라인 참고)……………………… 80
7. Colonic diverticula…………………………………………………………………… 82
8. Intestinal obstruction………………………………………………………………… 85
9. Colon polyp (대장 용종)… ………………………………………………………… 89
10. Functional Dyspepsia……………………………………………………………… 93
11. Irritable Bowel Syndrome… ……………………………………………………… 96

02 Hepatobiliary disease
1. Liver function test의 해석 … ……………………………………………………… 99
2. Acute hepatitis A… ……………………………………………………………… 103
3. Chronic Hepatitis B ……………………………………………………………… 104
4. Chronic Hepatitis C… …………………………………………………………… 114
5. Autoimmune hepatitis… ………………………………………………………… 119
6. Alcoholic hepatitis………………………………………………………………… 120
7. Ischemic hepatitis (shock liver)… ……………………………………………… 122
8. Liver abscess (pyogenic, amebic) ……………………………………………… 122
9. Acute hepatitis/acute hepatic failure…………………………………………… 123
10. Drug induced liver injury … …………………………………………………… 125
11. Cirrhosis… ……………………………………………………………………… 127
12. Gastroesophageal Varices & Variceal Hemorrhage………………………… 129
13. Ascites… ………………………………………………………………………… 133
14. Spontaneous bacterial peritonitis (SBP)……………………………………… 136
15. Hepatic encephalopathy… …………………………………………………… 137
16. Hepatorenal syndrome… ……………………………………………………… 139
17. HCC (hepatocellular carcinoma) ……………………………………………… 141
18. Biliary Tract Disease …………………………………………………………… 146
19. Pancreatitis… …………………………………………………………………… 153
20. EUS (Endoscopic ultrasonography)… ……………………………………… 160
21. Tumor in pancreas ……………………………………………………………… 160

03 Cardiology
1. Ischemic heart disease…………………………………………………………… 163
2. Heart Failure… …………………………………………………………………… 184
3. 심근질환… ………………………………………………………………………… 195
4. Valvular Heart Disease…………………………………………………………… 200
4-1. Mitral Stenosis (MS)………………………………………………………… 200
4-2. Mitral Regurgitation (MR)…………………………………………………… 204
4-3. Aortic Stenosis (AS)………………………………………………………… 208
4-4. Aortic Regurgitation (AR)…………………………………………………… 212
4-5. Preop. evaluation pathway for VHD in SMC… ………………………… 216
4-6. 판막질환 환자에서의 항응고 요법… ……………………………………… 217
5. 심낭질환… ………………………………………………………………………… 220
6. Arrhythmia… ……………………………………………………………………… 226
7. Syncope… ………………………………………………………………………… 253
8. Hypertension… …………………………………………………………………… 257
9. Aorta Disease……………………………………………………………………… 262
10. Peripheral artery diseases (PAD)……………………………………………… 267
10-1. Ischemic limb disease…………………………………………………… 268
10-2. Extracranial Carotid Stenosis … ……………………………………… 272
11. 혈관염(Vasculitis)………………………………………………………………… 273
11-1. 타카야수 동맥염(Takayasu’s arteritis)… ……………………………… 273
11-2. 버거씨 병(Buerger’s disease, TAO; thromboangiitis obliterans)…… 275
12. Pulmonary Hypertension (ESC guideline 2015)… ………………………… 276
13. Perioperative Cardiovascular Evaluation in Noncardiac Surgery ………… 280
14. BLS (Basic life support) and ACLS (Advanced cardiac life support) … … 283

04 Pulmonology
1. 호흡기 증상별 접근법… ………………………………………………………… 291
2. 호흡기 내과의 검사 방법들… …………………………………………………… 298
3. Pneumonia (폐렴)… ……………………………………………………………… 305
4. Lung abscess……………………………………………………………………… 321
5. Mycobacterial disease…………………………………………………………… 323
6. Bronchiectasis… ………………………………………………………………… 330
7. Chronic Obstructive Pulmonary Disease (만성폐쇄성 폐질환)……………… 332
8. Diffuse Interstitial Lung Disease (간질성 폐질환) … ………………………… 344
9. Diffuse panbronchiolitis………………………………………………………… 355
10. Pulmonary embolism…………………………………………………………… 357
11. Pleural effusion…………………………………………………………………… 364
12. 급성호흡부전(Acute respiratory failure)… …………………………………… 374
13. 기계환기의 기초… ……………………………………………………………… 376
14. Weaning from Mechanical Ventilation………………………………………… 380
15. Airway Management… ………………………………………………………… 385
16. Management of shock… ……………………………………………………… 388
17. Management of severe sepsis and septic shock … ……………………… 393

05 Endocrinology
1. DM (Diabetes Mellitus)…………………………………………………………… 397
2. 뇌하수체 질환 … ………………………………………………………………… 423
3. 갑상선 질환 … …………………………………………………………………… 427
4. Disorders of adrenal cortex……………………………………………………… 442
5. Pheochromocytoma……………………………………………………………… 454
6. Osteoporosis… …………………………………………………………………… 456
7. Disorders of lipoprotein metabolism (Dyslipidemias)………………………… 466

06 Nephrology
1. 요검사의 해석……………………………………………………………………… 473
2. Urine sediment… ………………………………………………………………… 474
3. GFR… ……………………………………………………………………………… 474
4. 단백뇨(proteinuria)………………………………………………………………… 476
5. 혈뇨환자의 접근 방법… ………………………………………………………… 479
6. 신생검(Renal biopsy)……………………………………………………………… 481
7. Renal imaging……………………………………………………………………… 483
8. 산염기 장애………………………………………………………………………… 485
9. Sodium and Water Homeostasis… …………………………………………… 492
10. Hyponatremia… ………………………………………………………………… 495
11. Hypernatremia…………………………………………………………………… 503
12. Diabetes insipidus… …………………………………………………………… 505
13. Potassium and calcium homeostasis………………………………………… 510
14. Phosphate and magnesium…………………………………………………… 521
15. Acute Kidney Injury……………………………………………………………… 522
16. Contrast nephropathy… ……………………………………………………… 528
17. Chronic kidney disease………………………………………………………… 531
18. CAPD exit site and tunnel infections (ISPD guidelines 2010)… ………… 548
19. CAPD peritonitis… ……………………………………………………………… 549
20. Vascular access for hemodialysis… ………………………………………… 554
21. 투석 적절도(Dialysis adequacy)의 평가… …………………………………… 557
22. 혈액 투석 합병증(Complication during dialysis)……………………………… 558
23. 이뇨제와 refractory edema… ………………………………………………… 560
24. Primary glomerulonephritis… ………………………………………………… 564
25. 전신 질환과 신장질환…………………………………………………………… 573

07 Hematology-Oncology
Ⅰ. Hematology
1. Thrombocytopenia… …………………………………………………………… 587
2. Immune thrombocytopenic purpura (ITP)… ………………………………… 589
3. TTP (Thrombotic thrombocytopenic purpura)………………………………… 591
4. HUS (Hemolytic uremic syndrome)… ………………………………………… 592
5. DIC (Disseminated intravascular coagulation)………………………………… 593
6. Approach to the adult patient with anemia…………………………………… 595
7. Iron deficiency anemia (IDA)… ………………………………………………… 597
8. Anemia of chronic disease (ACD)… …………………………………………… 599
9. Megaloblastic anemia… ………………………………………………………… 601
10. Hemolytic anemia… …………………………………………………………… 602
11. Approach to the adult patients with pancytopenia………………………… 604
12. Aplastic Anemia… ……………………………………………………………… 605
13. Myelodysplastic syndrome (MDS)… ………………………………………… 608
14. Polycythemia vera (PV)… ……………………………………………………… 611
15. Primary myelofibrosis (PMF)…………………………………………………… 613
16. Essential thrombocytosis (ET)… ……………………………………………… 614
17. Chronic Myelogenous Leukemia (CML)……………………………………… 615
18. Granulocyte-colony stimulating factor (G-CSF) and Erythropoietin……… 620
19. Transfusion medicine…………………………………………………………… 624
20. Introduction of Acute leukemia………………………………………………… 628
21. Acute Myelocytic Leukemia (AML)… ………………………………………… 631
22. Acute Lymphoid Leukemia (ALL)……………………………………………… 636
23. Hematopoietic stem cell transplantation (HSCT)…………………………… 639
24. Multiple Myeloma (MM)………………………………………………………… 649
25. Palpable lymph nodes… ……………………………………………………… 659
26. Non-Hodgkin’s lymphoma (NHL)…………………………………………… 661
27. Hodgkin’s Disease… ………………………………………………………… 664

Ⅱ. Oncology
1. Oncology overview … …………………………………………………………… 666
2. Chemotherapy overview… ……………………………………………………… 669
3. Pain control … …………………………………………………………………… 677
4. Antiemesis… ……………………………………………………………………… 686
5. Oncologic Emergencies ………………………………………………………… 690
6. Head and neck cancer…………………………………………………………… 697
7. Esophageal cancer … …………………………………………………………… 698
8. Breast cancer……………………………………………………………………… 699
9. Lung Cancer ……………………………………………………………………… 702
10. Stomach cancer ………………………………………………………………… 708
11. 완화의학… ……………………………………………………………………… 712

08 Infection
1. 발열 환자에 대한 임상적 접근…………………………………………………… 717
2. 세균 배양 검사 및 감수성 해석…………………………………………………… 720
3. 피부 연조직 감염… ……………………………………………………………… 722
4. 골관절 감염 … …………………………………………………………………… 726
5. 요로 감염증(Urinary tract infection, UTI)… …………………………………… 734
6. 복강내 감염(Intraabdominal infection)… ……………………………………… 739
7. 감염성 심내막염(infective endocarditis)………………………………………… 744
8. 카테터 관련 혈류감염(catheter-related bloodstream infection) … ………… 759
9. 급성 뇌수막염(Acute meningitis)………………………………………………… 770
10. 바이러스 감염증… ……………………………………………………………… 777
11. 인수공통감염증… ……………………………………………………………… 804
12. 진균 감염증… …………………………………………………………………… 808
13. Neutropenic fever… …………………………………………………………… 830
14. 말라리아 감염증(Malaria)… …………………………………………………… 835
15. 성인 예방 접종과 여행 의학(제 6차 대한감염학회 연수강좌, 2002)… …… 841
16. 장기 이식 환자의 감염증(Post-transplant infection)………………………… 847

09 Rheumatology
1. Approach to articular and musculoskeletal disorders… …………………… 855
2. 류마티스성 질환을 위한 임상병리 검사의 해석………………………………… 860
3. 류마티스 관절염(Rheumatoid arthritis)… ……………………………………… 863
4. Systemic Lupus Erythematosus(전신성 홍반성 낭창)… …………………… 871
5. Gout (monosodium urate gout)………………………………………………… 884
6. Spondyloarthropathies…………………………………………………………… 887
7. Vasculitis…………………………………………………………………………… 891
8. Sj?gren’s syndrome……………………………………………………………… 899
9. Behcet’s Disease… ……………………………………………………………… 902
10. Inflammatory Myopathy(염증성 근병증)……………………………………… 905
11. Scleroderma, Systemic sclerosis……………………………………………… 910
12. Adult Onset Still's Disease (AOSD)…………………………………………… 917
13. 섬유근통(Fibromyalgia)… ……………………………………………………… 921
14. 재발다발연골염(relapsing polychondritis)… ………………………………… 923

10 Allergy
1. 알레르기의 정의…………………………………………………………………… 925
2. 알레르기 질환에서의 검사… …………………………………………………… 925
3. Classification of allergic reactions (Gell and Coombs)… …………………… 929
4. Asthma(천식)… …………………………………………………………………… 929
5. Allergic rhinitis……………………………………………………………………… 940
6. Chronic cough… ………………………………………………………………… 947
7. Drug eruptions… ………………………………………………………………… 949
8. Anaphylaxis………………………………………………………………………… 951
9. Eosinophilia(호산구증가증)… …………………………………………………… 954
10. Urticaria and angioedema……………………………………………………… 958

11 Neurology
1. Neurologic examination… ……………………………………………………… 961
2. Coma… …………………………………………………………………………… 965
3. Stroke… …………………………………………………………………………… 973
4. Seizure……………………………………………………………………………… 975
5. Spinal cord, spinal nerve, and periphral nerve… …………………………… 984
6. Headache… ……………………………………………………………………… 986
Index…………………………………………………………………………………… 993