Protein Flexibility and Folding (Hardcover)

Flexibility and Dynamics. Applications of NMR for the characterization of protein dynamics and folding. Observation and simulation to study mechanical properties of proteins. Intrinsically disordered proteins. Predicting flexibility in proteins using constraint theory. Structure and dynamics of 6-hydroxymethyl-7, 8-dihydropterin pyrophosphokinase. Sampling activated mechanisms in proteins with the activation-relaxation technique. Folding and Unfolding. Constructing smooth potential functions for protein folding. Hydrogen exchange and protein folding. Structural transitions in neutral and charged proteins in vacuo. Capture and identification of folding intermediates of cystinyl proteins. Solid state NMR studies of membranes and membrane-bound systems. Molecular simulations and acid-induced protein unfolding. Molecular dynamics simulations on protein folding and protein structure prediction. Evolution and Design. Evolutionary perspectives on protein folding and stability. The designability of protein structures. Comparing protein structures: a Gaussain-based approach to the three-dimensional similarity of proteins.