Structural Bioinformatics (Hardcover)

Foreword.Preface.Acknowledgments.Contributors.SECTION I: INTRODUCTION.Defining Bioinformatics and Structural Bioinformatics (R. Altman&J. Dugan).Fundamentals of Protein Structure (E. Scheeff&J. Fink).Fundamentals of DNA and RNA Structure (S. Neidle, et al.).Computational Aspects of High-Throughput Crystallographic Macromolecular Structure Determination (P. Adams, et al.).Macromolecular Structure Determination by NMR Spectroscopy (J. Markley, et al.).Electron Microscopy (N. Volkmann&D. Hanein).Molecular Visualization (J. Tate).SECTION II: DATA REPRESENTATION AND DATABASES.The PDB Format, mmCIF Formats, and Other Data Formats (J. Westbrook&P. Fitzgerald).The Protein Data Bank (The PDB Team).The Nucleic Acid Database (H. Berman, et al.).Other Structure-Based Databases (H. Weissig&P. Bourne).SECTION III: COMPARATIVE FEATURES.Protein Structure Evolution and the SCOP Database (B. Reddy&P. Bourne).The CATH Domain Structure Database (C. Orengo, et al.).Structural Quality Assurance (R. Laskowski).All-Atom Contacts: A New Approach to Structure Validation (J. Richardson).Structure Comparison and Alignment (P. Bourne&I. Shindyalov).SECTION IV: STRUCTURE AND FUNCTIONAL ASSIGNMENT.Secondary Structure Assignment (C. Andersen&B. Rost).Identifying Structural Domains in Proteins (L. Wernisch&S. Wodak).Inferring Protein Function from Structure (G. Bartlett, et al.).SECTION V: PROTEIN INTERACTIONS.Prediction of Protein-Protein Interactions from Evolutionary Information (A. Valencia&F. Pazos).Electrostatic Interactions (N. Baker&J. McCammon).SECTION VI: PROTEINS AS DRUG TARGETS.Principles and Methods of Docking and Ligand Design (J. Krumrine, et al.).Structural Bioinformatics in Drug Discovery (E. Fauman, et al.).SECTION VII: STRUCTURE PREDICTION.CASP and CAFASP Experiments and Their Findings (P. Bourne).Homology Modeling (E. Krieger, et al.).Fold Recognition Methods (A. Godzik).Ab Initio Methods (D. Chivian, et al.).Prediction in 1D: Secondary Structure, Membrane Helices, and Accessibility (B. Rost).SECTION VIII: THE FUTURE.Structural Genomics (S. Burley&J. Bonanno).Index.