Statistical Mechanics and Stability of Macromolecules : Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DN (Paperback)

Preface; 1. Introduction; 2. Macromolecular stability; 3. Lattice dynamics; 4. Effective phonon theory; 5. Premelting disrupted chemical bonds; 6. Co-operative melting; 7. Strained chemical bonds: salt and pressure effects; 8. Bond disruption and conformation change: B to Z confirmation change in DNA; 9. Hydration effects: structural water; 10. Helix with daunomycin intercalated: increased helix stability and daunomycin-DNA bonding constant; 11. Non repeating DNA; 12. Cutting and splicing: junctions, inserts and the replicating fork; 13. Interaction between a helix and a single attached molecule; 14. Energy considerations in bond opening; Appendix 1; Appendix 2; Appendix 3. Index