Structured Biological Modelling (Hardcover)

Preface
Holistic Approaches for Data Acquisition in Cell Biology-The Basis for SBM
Holistic Versus Molecular Biological Methods: A Fundamental Complementarity Between Experimental Strategies
Selected Minimal-Invasive Techniques for Holistic Data Acquisition in Cell Biology
Analytical Light Microscopy
Analytical Electron Microscopy
Further Analytical Techniques with Relevance for SBM
Image Analysis
Cellular Biosensors: Powerful Electrical Devices for the Detection of Biomolecular Signals
Structured Biological Modelling (SBM)-Technique and Applications
The SBM Cycle
Preliminary Remarks about the Modelling of Biological Systems
Structured Analysis
Mathematical Specification of the DFD Model
Stochastic Simulation of the Mathematical Model
SBM Applied to Intracellular Ca2+ Oscillations
The Experimental Basis
Critical Discussion of Minimal Models for Intracellular Ca2+ Oscillations
Microscopic View of Ca2+ Oscillators Represented by Stochastic Models: The Stochastic Two-Pool Oscillator
A SBM Model for Oscillatory Intracellular Ca2+ Waves in Nonexcitable Cells
Minimal Model of the Cellular Signal Transduction Network
The Cell Cycle
Modules of the Intracellular Signal Network
Structured Analysis of Proliferation-Associated Cell Signaling
The Minimal Model of the Mitogenic Signal Transduction Network: Discussion and Outlook
Emergence of Self-Organization in Tumor Biology
Brief Phenomenology of Self-Organized Cellular Structures
Physical Preliminaries
Phase Transitions in Cell Cycle and Neoplastic Growth
Neoplastic Growth as a Process of Cellular Self-Organization?
The Hierarchy of Biological Systems: Microenvironmental Hydrogen Ion Concentration as Central Order Parameter for Invasive Tumor Growth
Summary and Outlook
References