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· 분류 : 외국도서 > 과학/수학/생태 > 수학 > 확률과 통계 > 일반
· ISBN : 9781498709552
· 쪽수 : 310쪽
· 출판일 : 2016-06-22
목차
Why Conduct Phase I-II Trials?
The Conventional Paradigm
The Continual Reassessment Method
Problems with Conventional Dose-Finding Methods
The Phase I-II Paradigm
Efficacy and Toxicity
Elements of Phase I-II Designs
Treatment Regimes and Clinical Outcomes
Sequentially Adaptive Decision Making
Risk-Benefit Trade-Offs
Stickiness and Adaptive Randomization
Simulation as a Design Tool
Establishing Priors
Pathological Priors
Prior Effective Sample Size
Computing Priors from Elicited Values
Efficacy-Toxicity Trade-Off?Based Designs
General Structure
Probability Model
Admissibility Criteria
Trade-off Contours
Establishing a Prior
Steps for Constructing a Design
Illustration
Sensitivity to Target Contours
Sensitivity to Prior ESS
Trinary Outcomes
Time-to-Event Outcomes
Designs with Late-Onset Outcomes
A Common Logistical Problem
Late-Onset Events as Missing Data
Probability Model
Imputation of Delayed Outcomes
Illustration
Utility-Based Designs
Assigning Utilities to Outcomes
Subjectivity of Utilities
Utility-Based Sequential Decision Making
Optimizing Radiation Dose for Brain Tumors
Personalized Dose Finding
The EffTox Design with Covariates
Biomarker-Based Dose Finding
Combination Trials
Bivariate Binary Outcomes
Bivariate Ordinal Outcomes
Optimizing Molecularly Targeted Agents
Features of Targeted Agents
One Targeted Agent
Combining Targeted and Cytotoxic Agents
Combining Two Molecularly Targeted Agents
Optimizing Doses in Two Cycles
The Two-Cycle Problem
A Two-Cycle Model
Decision Criteria
Illustration
Simulation Study
Optimizing Dose and Schedule
Schedule Dependent Effects
Trinary Outcomes
Event Times Outcomes
Dealing with Dropouts
Dropouts and Missing Efficacy
Probability Model
Dose-Finding Algorithm
Simulations
Optimizing Intra-Arterial tPA
Rapid Treatment of Stroke
Probability Model
Decision Criteria and Trial Conduct
Priors
Simulations
Optimizing Sedative Dose in Preterm Infants
Respiratory Distress Syndrome in Neonates
Clinical Outcomes and Probability Model
Prior and Likelihood
Decision Criteria
Simulations
Bibliography
