Carbonic Anhydrase as Drug Target: Thermodynamics and Structure of Inhibitor Binding (Hardcover, 2019)

Final ToC tbd. 1) Description of human carbonic anhydrases (12 catalytically active human isoforms; isoforms as drug targets, enzymatic activity, catalytic mechanism, thermodynamics of protonation of the water molecule in the active site).- 2) Thermal stabilities of all isoform CA catalytic domains.- Thermodynamics of inhibitor binding to CAs (incl. intrinsic thermodynamics - not mentioned important subject in most CA literature).- 3) Comparison of methods to determine inhibitor binding to CAs (ITC, FTSA, enzymatic activity assays).- 4) Chemical synthesis of CA inhibitors.- 5) X-ray crystallographic structures of CAs and their complexes with inhibitors.- 6) Antibodies against CAs.