Handbook of C-H Transformations, 2 Volume Set: Applications in Organic Synthesis (Hardcover)

INTRODUCTION AND BACKGROUND
CH ACTIVATION AT SP-HYBRIDIZED CARBON ATOMS
At terminal alkynes
- base-induced or catalyzed addition of terminal alkynes to elektrophiles
- Sonogashira coupling reaction
- Glaser coupling reaction
At HCN
- hydrocyanation of alkenes and alkynes
- enantioselective addition of HCN to carbonyl compounds
CH ACTIVATION AT SP2-HYBRIDIZED CARBON ATOMS
At arenes
- CO-bond formation by oxidation
- by stoichiometric oxidants
- by enzymes
- supported by artificial transition metal catalysts
- towards industrial application: addition to unfunctionalized olefines
- Rh-catalyzed carbonylation
- Rh-catalyzed and Pt-catalyzed silylation
- ortho-selective alkylation of arenes
- DOM reaction
- intermolecular Pd-catalyzed arylations
- Pd-catalyzed arylations via palladacycles
- oxidative vinylation: Pd-catalyzed in comparison to Rh-catalyzed processes
At alkenes
- via cyclometallated Ru-complexes (or: Ru-catalyzed activation of alkenyl esters)
- via cyclometallated Rh-complexes
- Heck reaction
- via cyclopalladation
- Wacker oxidation
At aldehydes
- via cyclopalladation
- via cyclometallation with rhodium catalysts
- inter- and intramolecular (enantioselective) hydroacylation
CH ACTIVATION AT SP3-HYBRIDIZED CARBON ATOMS
At functionalized alkanes
- in allylic and benzylic position
- via palladacycles
- via cyclometallated complexes
- in a-position of nitriles
- asymmetric aldol reactions and related reactions
- oxidative free-radical Cyclizations with b-dicarbonyl compounds
- aerobic oxidation of alcohols
At unfunctionalized alkanes
- CO-bond formation by oxidation
- radicalic halogenation
- photochemical processes
- heterogenic catalysis by silica supported hydrido tantalum
- Pd-catalyzed carboxylation
- olefines by transition metal catalyzed dehydrogenation