Bioinorganic Chemistry: A Short Course (Paperback, 3)

· 제목 : Bioinorganic Chemistry: A Short Course (Paperback, 3) 
· 분류 : 외국도서 > 과학/수학/생태 > 과학 > 생명과학 > 생화학
· ISBN : 9781119535218
· 쪽수 : 350쪽

Preface

Acknowledgments

Chapter 1 Inorganic Chemistry and Biochemistry Essentials

1.1 Introduction

1.2 Essential Chemical Elements

1.3 Inorganic Chemistry Basics

1.4 Electronic and Geometric Structures of Metals in Biological Systems

1.5 Thermodynamics and Kinetics

1.6 Bioorganometallic Chemistry

1.7 Inorganic Chemistry Conclusions

1.8 Introduction to Biochemistry

1.9 Proteins

1.9.1 Amino Acid Building Blocks

1.9.2 Protein Structure

1.9.3 Protein Function, Enzymes and Enzyme Kinetics

1.10 DNA and RNA Building Blocks

1.10.2 DNA and RNA Molecular Structures

1.10.3 Transmission of Genetic Information

1.10.4 Genetic Mutations and Site-Directed Mutagenesis

1.10.5 Genes and Cloning

1.10.6 Genomics and The Human Genome

1.10.7 CRISPR

1.11 A Descriptive Example: Electron Transport through DNA

1.11.1 Cyclic Voltammetry

1.12 Summary and Conclusions

1.13 Review Questions and Thought Problems

Chapter 2 Computer Hardware, Software, and Computational Chemistry Methods

2.1 Introduction to Computer-Based Methods

2.2 Computer Hardware

2.3 Computer Software for Chemistry

2.3.1 Chemical Drawing Programs

2.3.2 Visualization Programs

2.3.2.1 Molecular Dynamics Software

2.3.2.2 Mathematical and Graphing Software

2.4 Molecular Modeling, Molecular Mechanics, and Molecular dynamics

2.5 Quantum Mechanics-Based computational Methods

2.5.1 Ab Initio Methods

2.5.2 Semi-empirical Methods

2.5.3 Density Functional Theory and Examples

2.5.3.1 Starting with Schrödinger

2.5.3.2 Density Functional Theory

2.5.3.3 Basis Sets

2.5.3.4 DFT Applications

2.5.4 Quantum Mechanics/Molecular Mechanics (QM/MM) Methods

2.6 Conclusions on Hardware, Software and Computational Chemistry

2.7 Databases, Visualization Tools, Nomenclature and Other Online Resources

2.8 Questions and Thought Problems

Chapter 3 Important Metal Centers in Proteins

3.1 Iron centers in Myoglobin and Hemoglobin

3.1.1 Introduction

3.1.2 Structure and Function as Determined by X-ray Crystallography and Nuclear Magnetic Resonance

3.1.3 Cryo-Electron Microscopy and Hemoglobin Structure/Function

3.1.3.1 Introduction

3.1.3.2 Cryo-Electron Microscopy Techniques

3.1.3.3 Structures Determined Using Cryo-Electron Microscopy

3.1.4 Model Compounds

3.1.5 Blood Substitutes

3.2 Iron Centers in Cytochromes

3.2.1 Cytochrome c Oxidase

3.2.2 Cytochrome c Oxidase Structural Studies

3.2.3 Cytochrome c Oxidase Catalytic Cycle and Energy Considerations

3.2.4 Proton Channels in Cytochrome c Oxidase

3.2.5 Cytochrome c Oxidase Model Compounds

3.3 Iron sulfur clusters in Nitrogenase

3.3.1 Introduction

3.3.2 Nitrogenase Structure and Catalytic Mechanism

3.3.3 Mechanism of Dinitrogen (N₂) Reduction

3.3.4 Substrate Pathways into Nitrogenase

3.3.5 Nitrogenase Model Compounds

3.3.5.1 Functional Nitrogenase Models

 3.3.5.2 Structural Nitrogenase Models

3.4 Copper and Zinc in Superoxide Dismutase

3.4.1 Introduction

3.4.2 Superoxide Dismutase Structure and Mechanism of Catalytic Activity

3.4.3 A Copper Zinc Superoxide Dismutase Model Compound

3.5 Methane Monooxygenase

3.5.1 Introduction

3.5.2 Soluble Methane Monooxygenase

3.5.3 Particulate Methane Monooxygenase

3.6 Summary and Conclusions

3.7 Thought Problems

Chapter 4 Hydrogenases, Carbonic Anhydrases, Nitrogen Cycle Enzymes

Introduction

4.1 Hydrogenases

4.1.1 Introduction

4.1.2 [NiFe]-hydrogenases

4.1.2.1 [NiFe]-hydrogenase Model Compounds

4.1.3 [FeFe]-hydrogenases

4.1.3.1 [FeFe]-Hydrogenase Model Compounds

4.1.4 [Fe]-hydrogenases

4.1.4.1 [Fe]-Hydrogenase Model Compounds

4.2 Carbonic Anhydrases

4.2.1 Introduction

4.2.2 Carbonic Anhydrase Inhibitors

Section 4.3 Nitrogen Cycle Enzymes

4.3.1 Introduction

4.3.2 Nitric Oxide synthase

4.3.2.1 Introduction

4.3.2.2 Nitric Oxide Synthase Structure

4.3.2.3 Nitric Oxide Synthase Inhibitors

4.3.3 Nitrite Reductase

4.3.3.1 Introduction

4.3.3.2 Reduction of nitrite ion to ammonium ion

4.3.3.3 Reduction of nitrite ion to Nitric Oxide

4.4 Summary and conclusions

4.5 Thought Problems

Chapter 5 Nanobioinorganic Chemistry

5.1 Introduction to Nanomaterials

5.2 Analytical Methods

5.2.1 Microscopy

5.2.1.1 Scanning Electron Microscopy (SEM)

5.2.1.2 Transmision Electron Microscopy (TEM)

5.2.1.3 Scannin Transmission Electron Microscopy (STEM)

5.2.1.4 Cryo-Electron Microscopy

5.2.1.5 Scanning Probe Microscopy

5.2.1.6 Atomic Force Microscopy

5.2.1.7 Super-Resolution Microscopy and DNA-PAINT

5.2.2 Förster Resonance Energy Transfer (FRET)

5.3 DNA Origami

5.4 Metallized DNA Nanomaterials

5.4.1 Introduction

5.4.2 DNA-Coated Metal Electrodes

5.4.3 Plasmonics and DNA

5.5 Bioimaging with Nanomaterials, Nanomedicine, Cytotoxicity

5.5.1 Introduction

5.5.2 Imaging with Nanomaterials

5.5.3 Bioimaging using Quantum Dots

5.5.4 Nanoparticles in Therapeutic Nanomedicine

5.5.4.1 Clinical Nanomedicine

5.5.4.2 Some Drugs Formulated into Nanomaterials for Cancer Treatment: Cisplatinum, Platinum(IV) Prodrugs, and Doxorubicin

5.6 Theranostics

5.7 Nanoparticle Toxicity

5.8 Summary and Conclusions

5.9 Thought Problems

Chapter 6 Metals in Medicine

6.1 Platinum Anticancer Agents

6.1.1 Cisplatin Figure 6.1 (a)

6.1.2 Carboplatin (Paraplatin) Figure 6.1 (b)

6.1.3 Oxaliplatin Figure 6.1 (c)

6.1.4 Other cis-Platinum(II) Compounds

6.1.4.1 Nedaplatin (Figure 6.2)

6.1.4.2 Lobaplatin (Figure 6.2)

6.1.4.3 Heptaplatin (Figure 6.2)

6.1.5 Antitumor Active Trans Platinum compounds

6.1.6 Platinum Drug Resistance

6.1.7 Combination Therapies: Platinum-containing Drugs with Other Antitumor Compounds

6.1.8 Platinum(IV) Antitumor Drugs

6.1.8.1 Satraplatin Figure 6.1 (d)

6.1.8.2 Ormaplatin Figure 6.1 (e)

6.1.8.3 Iproplatin, JM9, CHIP Figure 6.1 (f)

6.1.9 Platinum(IV) Prodrugs

6.1.9.1 Multitargeted Platinum(IV) Prodrugs

6.1.9.2 Platinum(IV) Prodrugs Delivered via Nanoparticles

6.2 Ruthenium compounds as Anticancer Agents

6.2.1 Ruthenium(III) Anticancer Agents

6.2.2 Ruthenium(II) Anticancer Agents

6.2.3 Mechanism of Ruthenium(II) Anticancer Agent Activity

6.2.4 Other Ruthenium Compounds Tested for Antitumor Activity

6.3 Iridium and Osmium Antitumor Agents

6.4 Other Antitumor Agents

6.4.1 Gold Complexes

6.4.2 Titanium Complexes

6.4.3 Copper Complexes

6.5 Bismuth derivatives as antibacterials

6.6 Disease States and Treatments

6.6.1 Superoxide dismutases in disease states

6.6.2 Amyotrophic Lateral Sclerosis

6.6.3 Wilson’s and Menkes Diseases

6.6.4 Alzheimer’s disease

6.6.4.1 Role of Amyloid β Protein

6.6.4.2 Interactions of Aβ Peptides with Metals

6.6.4.3 Alzheimer’s Disease Treatments

6.7 Other Disease States Involving Metals

6.7.1 Copper and Zinc ions and Cataract Formation

6.7.2 As₂O₃, used in the treatment of acute promyelocytic leukemia (APL)

6.7.3 Vanadium Based Type 2 Diabetes Drugs

6.8 Summary and Conclusions

6.9 Questions Thought Problems