Radiotherapy Treatment Planning: Linear-Quadratic Radiobiology (Hardcover)

Introduction

Effects of Ionization Density and Volume
Ionizations along Charged-Particle Tracks
The ABCs of Charged-Particle Radiotherapy
The Frequency of Electron Track-Ends in Radiation Dose

Ionizing Events, Molecular Targets and Lethal Lesions
Time-Scale of Radiation-Induced Cellular Damages and Their Expression
The Oxygen Effect and Oxygen Enhancement Ratio (OER)
Radiation Events?The Role of Energy Density and Ionization Volume
The Molecular Target(s) for Cell Inactivation
DNA Lesions Produced by Radiation in Cellular DNA

The Radiosensitivity of Tumor Cells In Vitro versus In Vivo
The Radiosensitivity of Cells Irradiated in Multicellular Spheroids
The Radiosensitivity of Rodent Tumor Cells
Appropriate Inactivation Parameters for Modeling Human Tumor Response

Modern Radiobiology and the LQ Equation
Molecular Biology Factors of α- and β-Inactivation
Low Dose Hypersensitivity (LDH)
Bystander Effects

Normal Tissues Radiobiology
Information Derived from In Vitro Studies of Normal Tissue Cell Lines
Therapeutic Ratio
Fractionation
Functional Subunits (FSUs) and the Volume Effect
A Summary of the QUANTEC Study