Metabolomics: Recent Advances and Future Applications (Hardcover, 2023)

· 제목 : Metabolomics: Recent Advances and Future Applications (Hardcover, 2023) 
· 분류 : 외국도서 > 과학/수학/생태 > 과학 > 화학 > 유기화학
· ISBN : 9783031390937
· 쪽수 : 517쪽
· 출판일 : 2023-10-25

(1)??? Introduction of metabolomics:

(a)??? Definitions and significance

(b)??? Types of metabolomics: ESI-Mass spec, CE-MS, FTIR, NMR, GC-MS, MALDI,?

(c)???? Sample preparation: current technologies and trends

(d)??? Methods of separations: Isotope labeling, ion pairing, HILIC, ion mobility

(e)??? General application of metabolomics in biology

Potential contributors: Gary Patti or Estelle Rathahao-Paris

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(2)??? Metabolomics Data Analysis and Tools

(a)??? Current and novel technical/analytical tools for metabolite identification, annotation, quantification and type of databases.

(b)??? Workflows for targeted and untargeted (discovery) metabolomics and technical challenges.

(c)???? In silico spectra and structure prediction and molecular networking.

(d)??? Pathway analysis and annotation tools and platforms.

Potential contributors: Gary Siuzdak or Uwe Sauer

(3)??? Role of metabolomics in the development of new avenues in fundamental biology research.

(a)??? Functional metabolomics and its application in basic biology.

(b)??? Metabolomics with system biology for novel gene and pathway discovery

?????? Potential contributors: Joshua D. Rabinowitz or James J. Collins

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(4)??? Metabolomics in epidemiology:

(a)??? Identification of disease biomarkers

(b)??? Potential of metabolomics for clinical translation

(c)???? Data integration and management across studies and laboratory platforms (quality control, and statistical, bioinformatics, and analytical methods for large-scale studies).

Potential contributors: Elaine Holmes or Oliver Fiehn

(5)??? Pharmacometabolomics: General use of metabolomics in pharmacy and drug development.

(a)??? In drug discovery

(b)??? In novel target identification

(c)???? To understand drug resistance

(d)??? Role of metabolomics in precision medicine

Potential contributors: Jeremy K Nicholson and John C. Lindon

?

(6)??? Metabolomics in microbiological research and applications.

(a)??? Activity-based metabolomic profiling (ABMP)

(b)??? Interactions of gut microbiota and metabolic cooperation

(c)???? In bacterial diseases and diagnosis

(d)??? Microbial metabolic engineering and its application

Potential contributors: Luiz Pedro S de Carvalho and Hyungjin Eoh

(7)??? Application and developments of metabolomics in physiological diseases

(a)??? In cancer therapeutic development and diagnosis

(b)??? In neurobiology and disorders.

(c)???? In cardiovascular health and disease.

Potential contributors: David S Wishart or Peter Meikle

?

(8)??? ?Nutrimetabolomics: metabolomics in nutrition research

(a)??? In food component analysis and in food quality assessment

(b)??? In physiological monitoring of diet and nutrition studies

(c)???? In the study of diet-related diseases

(d)??? In dietary biomarkers

(e)??? Precision nutrition

Potential contributors: Soumeya Bekri or D. A. Volmer

(9)??? ?Metabolomics in natural product discovery and their application.

(a)??? Metabolomic workflow and database in natural product discovery.?

(b)??? Dereplication strategies in natural products identification.

Potential contributors: Carolyn M.Slupskyab or E.-Hu Liu

(10) Metabolomics approach in environmental studies

(a)??? To understand the environmental health paradigm

(b)??? In xenometabolomics and ecotoxicology studies

(c)???? Relations between the exposome and health consequences

Potential contributors: Emma Schymanski, or Ronald S. Tjeerdema

?

(11) Emerging metabolomics methodologies, and research in agriculture:

(a)??? Application in plant nutrient development

(b)??? In stress (drought, salt, and temperature) tolerance

(c)???? In germplasm fitness and diversity.

Potential contributors: Ute Roessner, William P. Ridley, Unclaimed, James H. Westwood

?

(12) Metabolomics in fundamental plant research
(a) To understand plant physiology

(b)??? In plant pathology and disease cure

(c)???? In novel gene identifications and their functional characterization.

(d)??? In plant biomarker identification

Potential contributors: Biswapriya Biswavas Misra, or De-Yu Xie

?

(13) Integration of metabolomics with other omics: tools and general applications

(a)??? Spatial metabolomics using imaging mass spectrometry

(b)??? With Transcriptomics, Proteomics, Genomics, Metagenomics, and Nutrigenomics

Potential contributors: Jens Nielsen or D. Branch Moody

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(14) Future perspectives of metabolomics: gaps, recommendations, and planning

(a)??? Challenges in metabolomics and how it can be solved in the coming time?

(b)??? Use of AI (artificial intelligence) in metabolomics big data mining and analysis

(c)???? Single-cell metabolomics

(d)??? Metabolic sensors and future of healthcare

Potential contributors: Kazuki Saito, Gary Siuzdak, Guowang Xu, Xi-jun Wang