Stress Proteins (Hardcover, 1999)

1 Stress Proteins: An Overview.- A. Introduction.- B. The Stress Proteins.- C. Functions of Stress Proteins.- D. Hsp Expression and Regulation.- E. Stress Proteins and Protection.- F. Stress Proteins and Human Disease.- G. Conclusion.- 2 The Hsp90 Chaperone Family.- A. General Aspects.- B. The Early Protein Folding Complex.- C. Hsp90-Containing Multimolecular Complexes.- I. The Steroid Receptor-Associated Hsp90-Containing Intermediate Folding Complex.- II. The Steroid Receptor-Associated Hsp90-Containing Mature Folding Complex.- D. Individual Chaperone and Co-chaperone Proteins Found in Hsp90 Complexes.- I. Hsp70.- II. p48Hip.- III. p60Hop.- IV. p23.- V. Immunophilins.- VI. Other TPR-Containing Proteins.- VII. p50Cdc37.- E. Refolding of Denatured Proteins.- F. Benzoquinone Ansamycins and Nucleotide Binding to Hsp90.- G. Hsp90 Client Proteins.- I. Transcription Factors.- 1. Steroid Receptors.- 2. Aryl Hydrocarbon Receptor.- 3. Mutated p53.- 4. Heat Shock Factor.- II. Protein Kinases.- 1. Tyrosine Kinases.- a) The Src Family Kinases.- b) Weel Kinase.- c) Sevenless Tyrosine Kinase.- d) Receptor Tyrosine Kinases - pl85erbB2.- 2. Serine/Threonine Kinases.- a) Raf-1 Kinase.- b) Casein Kinase II.- c) Heme-Regulated eIF-2? Kinase (HRI).- d) Cdk4/Cdk6.- III. Other Proteins.- 1. Cytoskeletal Proteins.- 2. Calmodulin.- 3. ß?-Subunits of Trimeric GTP-Binding Proteins.- 4. Proteasome.- 5. Hepadnavirus Reverse Transcriptase.- 6. Tumor Necrosis Factor Receptor and Retinoblastoma Protein.- H. Hsp90 and Drug Development.- I. Conclusion.- References.- 3 Heat Shock Protein 70.- A. Introduction.- B. Expression and Function of hsp70.- I. Hsp70, Transient Thermotolerance and Permanent Heat Resistance.- II. Hsp70 and Apoptosis.- III. Hsp70 Protects Cells from Oxidative Stress.- IV. Hsp70 Protects Cells from X-Ray Damage.- V. Hsp70 as Molecular Chaperone.- C. Regulation of hsp70.- I. Heat Shock Transcription Factor (HSF), the Transcriptional Regulator of hsp70.- II Signal Transduction Leading to Modulation of hsp70 Levels.- III. Negative Regulatory Effect of ERK1 on hsp70 Gene Expression.- IV. Mutational Analysis of HSF-1 Phosphorylation by ERK1 Protein Kinase.- V. Modulation of HSF-1 by Other Protein Kinases.- VI. Implication of HSF-1 Regulation by Functionally Opposing Signaling Cascades.- VII. Regulation of Heat Shock Response: Possible Involvement of Ku Autoantigen.- References.- 4 Mitochondrial Molecular Chaperones hsp60 and mhsp70: Are Their Roles Restricted to Mitochondria?.- A. Introduction.- B. Structure and function.- I. Studies with Purified Proteins.- 1. Hsp70/DnaK.- 2. Hsp60/GroEL.- II. In Vivo and Mitochondrial Systems.- C. Are hsp60 and mhsp70 Restricted to Mitochondria?.- I. Subcellular Localization: The Unexplained Findings.- II. Consideration of Possible Artifacts.- III. Possible Extramitochondrial Functions.- IV. Proposed Transport Mechanisms.- D. Hsp60 in Drug Resistance and Disease.- E. Future Prospects.- References.- 5 Role of Hsp27 and Related Proteins.- A. Introduction.- B. sHsp Genes and Control of Their Expression.- I. The Family of SHsp and the Structure of the Genes Encoding These Proteins.- II. Regulation of the Expression of sHsp Genes by Heat Shock.- III. Regulation of the Constitutive and Hormone-Dependent Expression of sHsp Genes.- IV. Tissue-Specific sHsp Expression During Development and in Adult Organisms.- V. Specific sHsp Expression During Early Differentiation.- VI. Pathological sHsp Expression and Associated Diseases.- C. Biochemical Properties of sHsp.- I. Structural Organization of sHsp.- II. Quaternary Structure of sHsp.- III. Phosphorylation of sHsp.- IV. Cellular Localization of sHsp.- D. Functions of sHsp.- I. sHsp Expression Induces Thermotolerance and Protects Cytoskeletal Architecture.- II. sHsp Act as Protein Chaperones.- III. sHsp Protection Against TNF and Oxidative Stress Inducers.- IV. sHsp Expression Protects Against Apoptosis.- 1. sHsp Interfere with In Vitro-Mediated Apoptosis.- 2. sHsp as