Introduction to Genomic Signal Processing with Control (Hardcover)

INTRODUCTIONREVIEW OF ORGANIC CHEMISTRYElectrovalent and Covalent BondsSome Chemical Bonds and Groups Commonly Encountered in Biological Molecules Building Blocks for Common Organic Molecules ENERGY CONSIDERATIONS IN BIOCHEMICAL REACTIONSSome Common Biochemical Reactions Role of Enzymes Feasibility of Chemical ReactionsActivated Carrier Molecules and Their Role in BiosynthesisPROTEINSProtein Structure and FunctionLevels of Organization in ProteinsProtein Ligand Interactions Isolating Proteins from CellsSeparating a Mixture of Proteins Protein Structure Determination Proteins That Are Enzymes DNATRANSCRIPTION AND TRANSLATIONTranscription Translation CHROMOSOMES AND GENE REGULATIONOrganization of DNA into Chromosomes Gene Regulation GENETIC VARIATIONGenetic Variation in BacteriaSources of Genetic Change in Eucaryotic Genomes DNA TECHNOLOGYTechniques for Analyzing DNA Molecules Nucleic Acid Hybridization and Associated Techniques Construction of Human Genomic and cDNA Libraries Polymerase Chain Reaction (PCR)Genetic Engineering CELL DIVISIONMitosis and Cytokinesis MeiosisCELL CYCLE CONTROL, CELL DEATH AND CANCERCyclin-Dependent Kinases and Their RoleControl of Cell Numbers in Multicellular Organisms Programmed Cell Death Cancer as the Breakdown of Cell Cycle Control EXPRESSION MICROARRAYScDNA Microarrays Synthetic Oligonucleotide Arrays CLASSIFICATIONClassifier Design Feature Selection Error Estimation CLUSTERINGExamples of Clustering Algorithms Clustering Accuracy Cluster Validation GENETIC REGULATORY NETWORKSNonlinear Dynamical Modeling of Gene Networks Boolean Networks Probabilistic Boolean Networks Network Inference INTERVENTIONPBN NotationIntervention by Flipping the Status of a Single Gene Intervention to Alter the Steady-State Behavior EXTERNAL INTERVENTION BASED ON OPTIMAL CONTROL THEORYFinite Horizon Control External Intervention in the Imperfect Information Case External Intervention in the Context-Sensitive Case External Intervention for a Family of Boolean Networks External Intervention in the Infinite Horizon Case Concluding Remarks References Index