Protac-Mediated Protein Degradation: A Paradigm Shift in Cancer Therapeutics (Hardcover, 2024)

1. Understanding the Ubiquitin Proteasome System - History and Revolution.-?2. PROTACs: Principles and Mechanisms.-?3. Structural Considerations and Chemistry of PROTAC.-?4. Advantages and Disadvantages of PROTACs.-?5. Novel Technologies in PROTAC Design.-?6. Future of trends in the design and development of PROTAC.-?7. Global Regulatory Requirements Applicable for PROTACs.-?8. Tissue-Specific Targeting Strategies with PROTAC Technology.-?9. Clinical Development OF PROTACs.-?10. Toxicological Aspects of PROTACs.-?11. PROTACs in the management of Prostate Cancer.- 12.?Exploring the Role of PROTACs for the Treatment of Breast Cancer.- 13.?Role of PROTACs in Hematological Malignancies.- 14.?Artificial Intelligence and Machine Learning for Exploring PROTAC in Underutilized Cells.- 15.?PROTACs in Treatment of Glioma.- 16.?Proteolysis Targeting Chimera (PROTACs) an Attractive Technology in CVD Therapeutics: Opportunities and Challenges.- 17.?Delivery systems - miniaturised PROTAC, Nano PROTAC, Aptamer-based RNA PROTAC.