Industrial Microbiology (Paperback)

HISTORIC OVERVIEW AND FUTURE PERSPECTIVES
Application of fermentation processes without knowledge of microorganisms (Neolithic period until 1850)
Investigation of microorganisms and beginning of industrial microbiology (1850 until 1940)
Development of new products and processes: antibiotics and other biomolecules (after 1940)
Genetic engineering as successful tool for industrial microorganisms (after 1980)
Synthetic Microbiology: Artificial pathways, designed microbes
BIOPROCESS ENGINEERING
Introduction
Non-structured models
Oxygen transport
Heat generating aerobic processes
Product recovery
Modeling and simulation of reactor behavior
Scale-up
Perspectives
FOOD
Fermented foods
Microorganisms and metabolism
Yeast fermentations- Industrial application of Saccharomyces species
Vinegar - Incomplete ethanol oxidation by acetic acid bacteria such as Gluconobacter oxidans
Bacterial and mixed fermentations- Industrial application of lactic acid bacteria, with or without yeast or molds
Fungi as food
Conclusions and outlook
INDUSTRIAL ALCOHOLS AND KETONES
Introduction
Ethanol
1,3 Propanediol
n-Butanol and isobutanol
Acetone
Perspectives
ORGANIC ACIDS
Introduction
Citric acid
Lactic acid
Gluconic acid
Succinic acid
Itaconic acid
Downstream options for organic acids
Perspectives
AMINO ACIDS
Introduction
Production of amino acids
L-Glutamate synthesis by Corynebacterium glutamicum
L-Lysine
L-Threonine synthesis by Escherichia coli
L-Phenylalanine
Outlook
VITAMINS, NUCLEOTIDES, AND CAROTENOIDS
Application and economic impact
L-Ascorbic acid (vitamin C)
Riboflavin (vitamin B2)
Cobalamin (vitamin B12)
Purine nucleotides
beta-Carotene
Perspectives
ANTIBIOTICS AND PHARMACOLOGICALLY ACTIVE COMPOUNDS
Microbial substances active against infectious disease agents or affecting human cells
beta-Lactams
Lipopeptides
Macrolides
Tetracyclines
Aminoglycosides
Claviceps alkaloids
Perspectives
PHARMACEUTICAL PROTEINS
History, main areas of application and economic importance
Industrial expression systems, cultivation and protein isolation and legal framework
Insulins
Somatropin
Interferons -
Application and manufacturing
Human granulocyte colony-stimulating factor
Vaccines
Antibody fragments
Enzymes
Peptides
View -
Future economic importance
ENZYMES
Fields of application and economic impacts
Rescue of enzymes
Polysaccharide-hydrolyzing enzymes
Enzymes used as cleaning agents
Feed supplements - phytases and xylanases
Industrial enzymes for chemical industry - lipases and alcohol dehydrogenases
Enzymes as tools in bio-analysis
Perspectives
POLYSACCHARIDES
Introduction
Heteropolysaccharides
Homopolysaccharides
Perspectives
STEROIDS
Fields of applications and economic importance
Advantages of biotransformations during production of steroids
Development of production strains and production processes
Applied types of biotransformation
Synthesis of steroids in organic-aqueous biphasic systems
Side chain degradation at phytosterols by Mycobacterium to gain steroid intermediates
Biotransformation of cholesterol to gain key steroid intermediates
11-Hydroxylation by fungi during synthesis of corticosteroids
delta1-dehydrogenation by Arthrobacter for the production of prednisolone
17-keto reduction by Saccharomyces in testosterone production
Double bond isomerization of steroids
Perspectives
BIOLEACHING
Mineral-oxidizing acidophilic bacteria dissolve metals from sulfide ores
Copper, nickel, zinc and cobalt
Gold
Uranium
Perspectives
WASTEWATER TREATMENT PROCESSES
Introduction
Biological basics of carbon, nitrogen and phosphorus removal
Wastewater treatment processes
Advanced wastewater treatment
Future perspectives